October 28, 2021
National Cancer Center Japan
´ºÓêÖ±²¥app School of Medicine
University of Miyazaki
Kyoto University
Japan Agency for Medical Research and Development
We conducted a large-scale whole-genome sequencing analysis of 150 clinical specimens of adult T-cell leukemia/lymphoma (ATL), a refractory hematological malignancy, and comprehensively identified various genomic abnormalities that could not be detected by conventional analyses.
Based on the genetic abnormalities identified through whole-genome sequencing, we identified disease states with different clinical features and prognoses and proposed a new classification of ATL based on this analysis.
The complete landscape of genomic abnormalities in ATL has been revealed, and the results of this research are expected to provide a foundation for the development of new diagnostic methods and therapeutic drugs. This study has once again demonstrated the importance of whole-genome sequencing in cancer research.
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